Sire design power calculation for QTL mapping experiments
نویسندگان
چکیده
منابع مشابه
The Power of QTL Mapping with RILs
QTL (quantitative trait loci) mapping is commonly used to identify genetic regions responsible to important phenotype variation. A common strategy of QTL mapping is to use recombinant inbred lines (RILs), which are usually established by several generations of inbreeding of an F1 population (usually up to F6 or F7 populations). As this inbreeding process involves a large amount of labor, we are...
متن کاملNovel Resampling Improves Statistical Power for Multiple-Trait QTL Mapping
Multiple-trait analysis typically employs models that associate a quantitative trait locus (QTL) with all of the traits. As a result, statistical power for QTL detection may not be optimal if the QTL contributes to the phenotypic variation in only a small proportion of the traits. Excluding QTL effects that contribute little to the test statistic can improve statistical power. In this article, ...
متن کاملResearch in QTL Analysis Searching for QTL in designed experiments
Designed experiments are employed to guarantee linkage disequilibrium between the genetic markers and the QTL, and also to limit the number of possible alleles segregating at a QTL. Many QTL studies in domestic livestock have used wide crosses, involving an economically relevant breed and a distantly related economically irrelevant breed. Alternatively, a number of large paternal halfsib famili...
متن کاملBayesian LASSO for QTL Mapping
Mapping quantitative trait loci (QTL) is to identify molecular markers or genomic loci that influence the variation of complex traits. The problem is complicated by the facts that QTL data usually contain a large number of markers across the entire genome and most of them have little or no effect on the phenotype. In this paper, we propose several Bayesian hierarchical models for mapping multip...
متن کاملR/qtl: high-throughput multiple QTL mapping
MOTIVATION R/qtl is free and powerful software for mapping and exploring quantitative trait loci (QTL). R/qtl provides a fully comprehensive range of methods for a wide range of experimental cross types. We recently added multiple QTL mapping (MQM) to R/qtl. MQM adds higher statistical power to detect and disentangle the effects of multiple linked and unlinked QTL compared with many other metho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 1999
ISSN: 0999-193X
DOI: 10.1051/gse:19990207